Year: 2015 | Month: December | Volume 5 | Issue 4
Effect of Aminoguanidine-Hemisulphate on Amikacin Induced Hematological Alterations in Wistar Rats
Abstract:
In the present study, haematological alterations induced by intraperitoneal administration of amikacin and the effect of aminoguanidine-hemisulphate alone and their combination was studied in wistar rats of either sex.Twenty-four healthy wistar rats divided into 4 groups (I, II, IIIand IV) were taken for the study. The intraperitoneal administration of amikacinat at a dose rate of 15 mg/kg body weight for 28 days (Group-II) caused a significant decrease in haematological parameters like Hb, PCV, TEC and TLC as compared to control-group. Although a significant increase in parameters was found in aminoguanidine treated-rats on day 15th and 29th as compared to day zero within same group. However after the co-administration of amikacin and aminoguanidine, a non-significant change was found in same parameters (Hb, TEC, PCV and TLC) as compared to control.
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